<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2021 Workiva-->
<!--r:0b549bbc-e1d0-4f80-8f4c-c5ed568a36b3,g:5a0d2240-139b-4a14-9d30-a4b7232a3f8a-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.bioscrip.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="bios-20210630.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesNoncurrent_23b1eb7a-f260-478a-a038-a3d6e86b112a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_8525e6a4-c69a-4165-8bdd-056b83fca7ba" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_23b1eb7a-f260-478a-a038-a3d6e86b112a" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_8525e6a4-c69a-4165-8bdd-056b83fca7ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_a1ec4b53-2e5b-4e3d-93d0-540282e37853" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_23b1eb7a-f260-478a-a038-a3d6e86b112a" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_a1ec4b53-2e5b-4e3d-93d0-540282e37853" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_f91cb77e-4a91-4b37-abb0-f5c53084d9e3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_23b1eb7a-f260-478a-a038-a3d6e86b112a" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_f91cb77e-4a91-4b37-abb0-f5c53084d9e3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_bfb65d02-f819-4365-aa2b-a65328f4aa14" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_23b1eb7a-f260-478a-a038-a3d6e86b112a" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_bfb65d02-f819-4365-aa2b-a65328f4aa14" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_6869b46b-913f-4cf7-94d5-76e2ed84e526" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_e41b7116-6861-4174-b69d-4d92eaff6779" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_6869b46b-913f-4cf7-94d5-76e2ed84e526" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_e41b7116-6861-4174-b69d-4d92eaff6779" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_9e7f7ee8-4e8b-43a0-a1f9-06e78b2a09b6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_6869b46b-913f-4cf7-94d5-76e2ed84e526" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_9e7f7ee8-4e8b-43a0-a1f9-06e78b2a09b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_8f3d7fbd-8b3f-49e1-b27b-95471ffaae73" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_6869b46b-913f-4cf7-94d5-76e2ed84e526" xlink:to="loc_us-gaap_InventoryNet_8f3d7fbd-8b3f-49e1-b27b-95471ffaae73" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_ac7b7c4e-51d0-49ca-9815-ef0604ad60ae" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_6869b46b-913f-4cf7-94d5-76e2ed84e526" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_ac7b7c4e-51d0-49ca-9815-ef0604ad60ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_ca7b31da-9f3f-4c39-ab83-d398437a6404" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_524f4e09-e279-48ae-a0b9-47d024de9dfb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_ca7b31da-9f3f-4c39-ab83-d398437a6404" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_524f4e09-e279-48ae-a0b9-47d024de9dfb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_8d9b6b31-bcad-424d-968c-d1b101ee02dd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_ca7b31da-9f3f-4c39-ab83-d398437a6404" xlink:to="loc_us-gaap_AccountsPayableCurrent_8d9b6b31-bcad-424d-968c-d1b101ee02dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_952c54d7-f171-48ae-b662-6b9e93aa32f6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_ca7b31da-9f3f-4c39-ab83-d398437a6404" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_952c54d7-f171-48ae-b662-6b9e93aa32f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bios_AccruedExpensesAndOtherCurrentLiabilities_7152e437-fcb2-4a6e-8096-8379490e0b21" xlink:href="bios-20210630.xsd#bios_AccruedExpensesAndOtherCurrentLiabilities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_ca7b31da-9f3f-4c39-ab83-d398437a6404" xlink:to="loc_bios_AccruedExpensesAndOtherCurrentLiabilities_7152e437-fcb2-4a6e-8096-8379490e0b21" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_9f26d57b-090d-48a4-85ac-50059e4c4cfc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_ca7b31da-9f3f-4c39-ab83-d398437a6404" xlink:to="loc_us-gaap_LongTermDebtCurrent_9f26d57b-090d-48a4-85ac-50059e4c4cfc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_61bc61eb-89b8-4e4d-bb67-6a7a103b1cf9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_9e08af2d-f384-4447-b2b3-41313998734a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_61bc61eb-89b8-4e4d-bb67-6a7a103b1cf9" xlink:to="loc_us-gaap_StockholdersEquity_9e08af2d-f384-4447-b2b3-41313998734a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_5c671d61-1d9c-4069-8862-29030d1cea0a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_61bc61eb-89b8-4e4d-bb67-6a7a103b1cf9" xlink:to="loc_us-gaap_Liabilities_5c671d61-1d9c-4069-8862-29030d1cea0a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_430c4019-e0e7-40bb-8011-ba091843f3b5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_e2ce1b0e-7940-4122-9354-bcdecba5738a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_430c4019-e0e7-40bb-8011-ba091843f3b5" xlink:to="loc_us-gaap_PreferredStockValue_e2ce1b0e-7940-4122-9354-bcdecba5738a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_7a2ff5b3-fc7b-4e9d-9150-86a1e707e1af" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_430c4019-e0e7-40bb-8011-ba091843f3b5" xlink:to="loc_us-gaap_CommonStockValue_7a2ff5b3-fc7b-4e9d-9150-86a1e707e1af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_485f119f-056f-4cf5-8fcf-a073fcce5bdf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockValue"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_430c4019-e0e7-40bb-8011-ba091843f3b5" xlink:to="loc_us-gaap_TreasuryStockValue_485f119f-056f-4cf5-8fcf-a073fcce5bdf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_7e89e257-eeac-4937-9365-29344c103eb6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_430c4019-e0e7-40bb-8011-ba091843f3b5" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_7e89e257-eeac-4937-9365-29344c103eb6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_5a6c8e2b-9da0-4c1f-8c3b-8250558b213c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_430c4019-e0e7-40bb-8011-ba091843f3b5" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_5a6c8e2b-9da0-4c1f-8c3b-8250558b213c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_077a484f-bff5-4643-aefe-7b8d7d3aa5bb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_430c4019-e0e7-40bb-8011-ba091843f3b5" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_077a484f-bff5-4643-aefe-7b8d7d3aa5bb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_2246d373-ea7b-43bf-ab0e-f0231bc2ab7b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_90302d49-0728-413d-a551-437dc6dfc018" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_2246d373-ea7b-43bf-ab0e-f0231bc2ab7b" xlink:to="loc_us-gaap_AssetsCurrent_90302d49-0728-413d-a551-437dc6dfc018" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsNoncurrent_9115c59f-8f0d-49e6-81b5-5a840ca9dcfc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_2246d373-ea7b-43bf-ab0e-f0231bc2ab7b" xlink:to="loc_us-gaap_AssetsNoncurrent_9115c59f-8f0d-49e6-81b5-5a840ca9dcfc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsNoncurrent_605de14f-bc2c-46e8-8e3f-821edc9349ac" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_a58dd522-e620-4293-baa9-9fca1059216f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsNoncurrent_605de14f-bc2c-46e8-8e3f-821edc9349ac" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_a58dd522-e620-4293-baa9-9fca1059216f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_a8fd7820-6875-418a-be29-04c9d4197edc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsNoncurrent_605de14f-bc2c-46e8-8e3f-821edc9349ac" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_a8fd7820-6875-418a-be29-04c9d4197edc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_35231357-f0f6-4b5a-9a71-5104e4b882d8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsNoncurrent_605de14f-bc2c-46e8-8e3f-821edc9349ac" xlink:to="loc_us-gaap_Goodwill_35231357-f0f6-4b5a-9a71-5104e4b882d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_c51fdc1b-97bb-410f-a392-8ec6ea9b06cb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsNoncurrent_605de14f-bc2c-46e8-8e3f-821edc9349ac" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_c51fdc1b-97bb-410f-a392-8ec6ea9b06cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_d4df9e2a-4afa-4964-b06f-54c5497f1269" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsNoncurrent_605de14f-bc2c-46e8-8e3f-821edc9349ac" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_d4df9e2a-4afa-4964-b06f-54c5497f1269" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_38cdb03b-914a-47ba-9184-0e6d3417e4a8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_cb90c2c7-1bac-4072-b91e-f3b4c8eacc58" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_38cdb03b-914a-47ba-9184-0e6d3417e4a8" xlink:to="loc_us-gaap_LiabilitiesCurrent_cb90c2c7-1bac-4072-b91e-f3b4c8eacc58" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesNoncurrent_0fc159ca-0f7e-4a38-9c84-6e67da792d8f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_38cdb03b-914a-47ba-9184-0e6d3417e4a8" xlink:to="loc_us-gaap_LiabilitiesNoncurrent_0fc159ca-0f7e-4a38-9c84-6e67da792d8f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.bioscrip.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS" xlink:type="simple" xlink:href="bios-20210630.xsd#UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_7c0a3bbd-ed7c-4c52-814b-530d885f517f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_7ca9b37c-b702-4320-bbe6-0b3e7e0c51c0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_7c0a3bbd-ed7c-4c52-814b-530d885f517f" xlink:to="loc_us-gaap_GrossProfit_7ca9b37c-b702-4320-bbe6-0b3e7e0c51c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_249a03be-e32b-4f6e-b262-65994e96aa2a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_7c0a3bbd-ed7c-4c52-814b-530d885f517f" xlink:to="loc_us-gaap_OperatingExpenses_249a03be-e32b-4f6e-b262-65994e96aa2a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_faa9dfa9-4100-4603-83ec-6dee09fd9410" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_30799ec3-82cd-4afd-97cf-6ef4d5aca036" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_faa9dfa9-4100-4603-83ec-6dee09fd9410" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_30799ec3-82cd-4afd-97cf-6ef4d5aca036" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_ddbd1fc1-b223-4595-bf75-472a04db8d0b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_318bd728-f09c-4008-b173-834b7dbcab75" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_ddbd1fc1-b223-4595-bf75-472a04db8d0b" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_318bd728-f09c-4008-b173-834b7dbcab75" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_66afa2ab-8245-4ecf-add9-1fce10d5a1cd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_ddbd1fc1-b223-4595-bf75-472a04db8d0b" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_66afa2ab-8245-4ecf-add9-1fce10d5a1cd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossAttributableToParent_eb91d606-e7c1-4be6-8e6c-aa72bd4a161b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_f8202c0d-6d71-4393-bc57-7bed51ed24a9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossAttributableToParent_eb91d606-e7c1-4be6-8e6c-aa72bd4a161b" xlink:to="loc_us-gaap_OperatingIncomeLoss_f8202c0d-6d71-4393-bc57-7bed51ed24a9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_0374795e-daeb-4e70-8c76-24011361cf2e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossAttributableToParent_eb91d606-e7c1-4be6-8e6c-aa72bd4a161b" xlink:to="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_0374795e-daeb-4e70-8c76-24011361cf2e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_8b1b2158-dc3c-4c7f-aa7e-815543b84991" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_f51159a2-456a-4e95-939f-781f58406056" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_8b1b2158-dc3c-4c7f-aa7e-815543b84991" xlink:to="loc_us-gaap_InterestExpense_f51159a2-456a-4e95-939f-781f58406056" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeNet_9bcce016-f583-43a2-ad9c-62ea4d84d940" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentIncomeNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_8b1b2158-dc3c-4c7f-aa7e-815543b84991" xlink:to="loc_us-gaap_InvestmentIncomeNet_9bcce016-f583-43a2-ad9c-62ea4d84d940" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_2ea1558e-39ae-43bf-906b-14699228bf04" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_8b1b2158-dc3c-4c7f-aa7e-815543b84991" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_2ea1558e-39ae-43bf-906b-14699228bf04" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_72ca04ed-48ff-471a-875a-aa4c2325cbb7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossAttributableToParent_652bb5ba-fc4d-40b7-832c-8b680196f434" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_72ca04ed-48ff-471a-875a-aa4c2325cbb7" xlink:to="loc_us-gaap_IncomeLossAttributableToParent_652bb5ba-fc4d-40b7-832c-8b680196f434" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_7bf18852-f547-47a6-a477-6d4042636ccf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_72ca04ed-48ff-471a-875a-aa4c2325cbb7" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_7bf18852-f547-47a6-a477-6d4042636ccf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_f50ae636-b71c-4380-bd47-2bb7d1b4db42" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_ee4f2968-ef51-4a92-be19-070f5f81f92b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_f50ae636-b71c-4380-bd47-2bb7d1b4db42" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_ee4f2968-ef51-4a92-be19-070f5f81f92b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_0bd8db20-e6db-45d4-b2b0-3a50ce32a7ab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_f50ae636-b71c-4380-bd47-2bb7d1b4db42" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_0bd8db20-e6db-45d4-b2b0-3a50ce32a7ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_dfb277fd-df8f-4bac-9dda-8bdf3f5cd200" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_6b9b6521-3b93-4159-bcf8-e41fb52cc817" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_dfb277fd-df8f-4bac-9dda-8bdf3f5cd200" xlink:to="loc_us-gaap_NetIncomeLoss_6b9b6521-3b93-4159-bcf8-e41fb52cc817" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_9876a19f-5bb6-464c-b91e-93de07665340" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_dfb277fd-df8f-4bac-9dda-8bdf3f5cd200" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_9876a19f-5bb6-464c-b91e-93de07665340" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.bioscrip.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="bios-20210630.xsd#UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4d650dcc-87b2-45ab-8492-259718213354" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_b6e9e5eb-6e7d-4e1e-aaa9-1f8ebb0ee082" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4d650dcc-87b2-45ab-8492-259718213354" xlink:to="loc_us-gaap_NetIncomeLoss_b6e9e5eb-6e7d-4e1e-aaa9-1f8ebb0ee082" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAmortizationAndAccretionNet_653d5b6b-bf76-4192-a73a-f39c10c3e612" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepreciationAmortizationAndAccretionNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4d650dcc-87b2-45ab-8492-259718213354" xlink:to="loc_us-gaap_DepreciationAmortizationAndAccretionNet_653d5b6b-bf76-4192-a73a-f39c10c3e612" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bios_OperatingLeaseRightOfUseAssetAmortization_04756d3c-5699-4c25-886a-5eafeca3a0f4" xlink:href="bios-20210630.xsd#bios_OperatingLeaseRightOfUseAssetAmortization"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4d650dcc-87b2-45ab-8492-259718213354" xlink:to="loc_bios_OperatingLeaseRightOfUseAssetAmortization_04756d3c-5699-4c25-886a-5eafeca3a0f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_35e975ad-0672-4977-98ce-fd102f815018" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4d650dcc-87b2-45ab-8492-259718213354" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_35e975ad-0672-4977-98ce-fd102f815018" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_1210476a-64a1-4991-bbc3-234dbe6d6fce" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4d650dcc-87b2-45ab-8492-259718213354" xlink:to="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_1210476a-64a1-4991-bbc3-234dbe6d6fce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_d1beb2c0-a209-434c-bbd8-5c3b63fbd049" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4d650dcc-87b2-45ab-8492-259718213354" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_d1beb2c0-a209-434c-bbd8-5c3b63fbd049" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_6de73b76-5882-4215-a498-2c088dcdaba3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4d650dcc-87b2-45ab-8492-259718213354" xlink:to="loc_us-gaap_ShareBasedCompensation_6de73b76-5882-4215-a498-2c088dcdaba3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_22a04d51-2997-471f-bf8e-f8da1579b1e8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherOperatingActivitiesCashFlowStatement"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4d650dcc-87b2-45ab-8492-259718213354" xlink:to="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_22a04d51-2997-471f-bf8e-f8da1579b1e8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInReceivables_4ad8e01a-803c-4e8a-b287-d1d181abc08a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInReceivables"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4d650dcc-87b2-45ab-8492-259718213354" xlink:to="loc_us-gaap_IncreaseDecreaseInReceivables_4ad8e01a-803c-4e8a-b287-d1d181abc08a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_d5b8f123-5724-4ca9-af82-9214f8f69a8f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4d650dcc-87b2-45ab-8492-259718213354" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_d5b8f123-5724-4ca9-af82-9214f8f69a8f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_95d88cec-9539-49a2-bc02-cdc4845f38c5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4d650dcc-87b2-45ab-8492-259718213354" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_95d88cec-9539-49a2-bc02-cdc4845f38c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableTrade_59648e1c-6188-497b-8b71-a7c4719b1f57" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableTrade"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4d650dcc-87b2-45ab-8492-259718213354" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableTrade_59648e1c-6188-497b-8b71-a7c4719b1f57" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities_4b325225-b196-424f-8a23-54e89027440d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4d650dcc-87b2-45ab-8492-259718213354" xlink:to="loc_us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities_4b325225-b196-424f-8a23-54e89027440d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities_be0b335b-438c-4403-95a6-7a04da47b92b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4d650dcc-87b2-45ab-8492-259718213354" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities_be0b335b-438c-4403-95a6-7a04da47b92b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasePayments_d49ee6e2-5b76-46f6-956b-76698bc97c23" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeasePayments"/>
    <link:calculationArc order="15" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4d650dcc-87b2-45ab-8492-259718213354" xlink:to="loc_us-gaap_OperatingLeasePayments_d49ee6e2-5b76-46f6-956b-76698bc97c23" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssetsAndLiabilitiesNet_56b4eee1-b727-4aee-91eb-2838780b9076" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssetsAndLiabilitiesNet"/>
    <link:calculationArc order="16" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4d650dcc-87b2-45ab-8492-259718213354" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssetsAndLiabilitiesNet_56b4eee1-b727-4aee-91eb-2838780b9076" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bios_LossOnDiscontinuanceOfCashFlowHedgeDerivative_0baa2c1d-60e2-4162-88ba-cafd6e5bf1e8" xlink:href="bios-20210630.xsd#bios_LossOnDiscontinuanceOfCashFlowHedgeDerivative"/>
    <link:calculationArc order="17" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4d650dcc-87b2-45ab-8492-259718213354" xlink:to="loc_bios_LossOnDiscontinuanceOfCashFlowHedgeDerivative_0baa2c1d-60e2-4162-88ba-cafd6e5bf1e8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_c324ad80-2836-4c64-8dfd-152a9dc286bb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="18" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4d650dcc-87b2-45ab-8492-259718213354" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_c324ad80-2836-4c64-8dfd-152a9dc286bb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d2750f1f-b408-41c5-b0a8-68d4bc3bedbb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_37ac7803-6eff-457f-9574-a383e9d69f59" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d2750f1f-b408-41c5-b0a8-68d4bc3bedbb" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_37ac7803-6eff-457f-9574-a383e9d69f59" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_f2c17cdd-9348-400e-aaea-6cead7752eed" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d2750f1f-b408-41c5-b0a8-68d4bc3bedbb" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_f2c17cdd-9348-400e-aaea-6cead7752eed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_6b1f43e5-63f2-4188-a09a-59556fea1604" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d2750f1f-b408-41c5-b0a8-68d4bc3bedbb" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_6b1f43e5-63f2-4188-a09a-59556fea1604" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_efb61543-c23e-49f5-8340-f0d2f5c3f5ca" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_81535b7f-0163-48e2-a0ff-6c116b268322" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_efb61543-c23e-49f5-8340-f0d2f5c3f5ca" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_81535b7f-0163-48e2-a0ff-6c116b268322" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfDebt_bbf51e71-1ee2-4b8b-a6ef-5dd5bffd4ec4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepaymentsOfDebt"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_efb61543-c23e-49f5-8340-f0d2f5c3f5ca" xlink:to="loc_us-gaap_RepaymentsOfDebt_bbf51e71-1ee2-4b8b-a6ef-5dd5bffd4ec4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_fdba1078-0a2f-4b6e-8523-ea8169e3a110" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_efb61543-c23e-49f5-8340-f0d2f5c3f5ca" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_fdba1078-0a2f-4b6e-8523-ea8169e3a110" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfDebt_28eeba9d-38d3-4548-b354-690233ff0ba8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromIssuanceOfDebt"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_efb61543-c23e-49f5-8340-f0d2f5c3f5ca" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfDebt_28eeba9d-38d3-4548-b354-690233ff0ba8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtExtinguishmentCosts_074d4570-900b-43a6-a1f7-cf232b89e834" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfDebtExtinguishmentCosts"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_efb61543-c23e-49f5-8340-f0d2f5c3f5ca" xlink:to="loc_us-gaap_PaymentsOfDebtExtinguishmentCosts_074d4570-900b-43a6-a1f7-cf232b89e834" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForDepositsAppliedToDebtRetirements_6da1a5cd-a6f2-4188-8a82-727dbe310492" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForDepositsAppliedToDebtRetirements"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_efb61543-c23e-49f5-8340-f0d2f5c3f5ca" xlink:to="loc_us-gaap_PaymentsForDepositsAppliedToDebtRetirements_6da1a5cd-a6f2-4188-8a82-727dbe310492" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_19fcd466-1a0e-4d6d-aa38-6e12707b3140" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_efb61543-c23e-49f5-8340-f0d2f5c3f5ca" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_19fcd466-1a0e-4d6d-aa38-6e12707b3140" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_fcd91357-6b61-4971-9c1d-e03289c658f7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_c591af9d-4ff3-4254-aa53-768c25ee7819" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_fcd91357-6b61-4971-9c1d-e03289c658f7" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_c591af9d-4ff3-4254-aa53-768c25ee7819" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_031460c8-7576-48c6-8656-b177265d6f48" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_fcd91357-6b61-4971-9c1d-e03289c658f7" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_031460c8-7576-48c6-8656-b177265d6f48" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_934e24d8-3f96-4a74-8bc7-340c1e33e7f4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_fcd91357-6b61-4971-9c1d-e03289c658f7" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_934e24d8-3f96-4a74-8bc7-340c1e33e7f4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.bioscrip.com/role/EARNINGSLOSSPERSHAREScheduleofBasicandDilutedEarningsDetails" xlink:type="simple" xlink:href="bios-20210630.xsd#EARNINGSLOSSPERSHAREScheduleofBasicandDilutedEarningsDetails"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/EARNINGSLOSSPERSHAREScheduleofBasicandDilutedEarningsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_78d6086c-409d-4de9-a2d9-f89131627e04" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_9496bceb-9b58-444b-b873-d339504e0c70" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_78d6086c-409d-4de9-a2d9-f89131627e04" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_9496bceb-9b58-444b-b873-d339504e0c70" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_9247a5e4-83c1-41c9-93dd-6233716e81dc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_78d6086c-409d-4de9-a2d9-f89131627e04" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_9247a5e4-83c1-41c9-93dd-6233716e81dc" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.bioscrip.com/role/LEASESMaturitiesofLeaseLiabilitiesDetails" xlink:type="simple" xlink:href="bios-20210630.xsd#LEASESMaturitiesofLeaseLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/LEASESMaturitiesofLeaseLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_0dfb370c-e1bc-4506-b3af-d5fa6abdcce0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_e1d4db81-4262-4ab9-8142-bf41928462e3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_0dfb370c-e1bc-4506-b3af-d5fa6abdcce0" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_e1d4db81-4262-4ab9-8142-bf41928462e3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_6cfa072f-edcd-4e9e-b885-eae4fdb3627c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_0dfb370c-e1bc-4506-b3af-d5fa6abdcce0" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_6cfa072f-edcd-4e9e-b885-eae4fdb3627c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_f32dc227-659c-4e66-9141-3cfed0dc0aa4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_0dfb370c-e1bc-4506-b3af-d5fa6abdcce0" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_f32dc227-659c-4e66-9141-3cfed0dc0aa4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_ab9fca67-04d9-4620-bfe6-60e42b11319f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_0dfb370c-e1bc-4506-b3af-d5fa6abdcce0" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_ab9fca67-04d9-4620-bfe6-60e42b11319f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_42d21784-17fa-49a6-8921-d10642121fbe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_0dfb370c-e1bc-4506-b3af-d5fa6abdcce0" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_42d21784-17fa-49a6-8921-d10642121fbe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bios_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_9286a70c-3d43-4223-b2fb-8050da456822" xlink:href="bios-20210630.xsd#bios_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_0dfb370c-e1bc-4506-b3af-d5fa6abdcce0" xlink:to="loc_bios_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_9286a70c-3d43-4223-b2fb-8050da456822" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.bioscrip.com/role/LEASESMaturitiesofLeaseLiabilitiesDetails_1" xlink:type="simple" xlink:href="bios-20210630.xsd#LEASESMaturitiesofLeaseLiabilitiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/LEASESMaturitiesofLeaseLiabilitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_bb6006d0-6704-4ece-9e32-4ff56133fa37" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_3078792c-9632-47dc-9b0e-8a16468642ec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_bb6006d0-6704-4ece-9e32-4ff56133fa37" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_3078792c-9632-47dc-9b0e-8a16468642ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_b77c9101-96cd-4808-b52f-59a1220da5df" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_bb6006d0-6704-4ece-9e32-4ff56133fa37" xlink:to="loc_us-gaap_OperatingLeaseLiability_b77c9101-96cd-4808-b52f-59a1220da5df" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.bioscrip.com/role/PROPERTYANDEQUIPMENTDetails" xlink:type="simple" xlink:href="bios-20210630.xsd#PROPERTYANDEQUIPMENTDetails"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/PROPERTYANDEQUIPMENTDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_f54375e2-d699-4e4c-ab41-46316a291173" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_91e2c953-0b01-49a7-8f4f-60823a967801" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_f54375e2-d699-4e4c-ab41-46316a291173" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_91e2c953-0b01-49a7-8f4f-60823a967801" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_cc4d9bd8-f7dc-467d-bdb4-2e1674706424" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_f54375e2-d699-4e4c-ab41-46316a291173" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_cc4d9bd8-f7dc-467d-bdb4-2e1674706424" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.bioscrip.com/role/GOODWILLANDOTHERINTANGIBLEASSETSCarryingAmountandAccumulatedAmortizationofIntangibleAssetsDetails" xlink:type="simple" xlink:href="bios-20210630.xsd#GOODWILLANDOTHERINTANGIBLEASSETSCarryingAmountandAccumulatedAmortizationofIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/GOODWILLANDOTHERINTANGIBLEASSETSCarryingAmountandAccumulatedAmortizationofIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_49a7e82d-7b3a-441f-90b2-e3762ac9364d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_dc0dd892-50c2-48c2-ab4a-0cb174c79040" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_49a7e82d-7b3a-441f-90b2-e3762ac9364d" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_dc0dd892-50c2-48c2-ab4a-0cb174c79040" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_4efed6ac-62cc-4175-a5e7-ed2195787d19" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_49a7e82d-7b3a-441f-90b2-e3762ac9364d" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_4efed6ac-62cc-4175-a5e7-ed2195787d19" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.bioscrip.com/role/INDEBTEDNESSSummaryofDebtDetails" xlink:type="simple" xlink:href="bios-20210630.xsd#INDEBTEDNESSSummaryofDebtDetails"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/INDEBTEDNESSSummaryofDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_2e2ef422-56dc-45d4-8f11-6d6de5e291e9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_4447ef15-6dda-48ed-a002-5f47820b33f3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_2e2ef422-56dc-45d4-8f11-6d6de5e291e9" xlink:to="loc_us-gaap_LongTermDebtCurrent_4447ef15-6dda-48ed-a002-5f47820b33f3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_d9999df0-580a-4d0d-8e0f-44605b9f6a80" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_2e2ef422-56dc-45d4-8f11-6d6de5e291e9" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_d9999df0-580a-4d0d-8e0f-44605b9f6a80" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.bioscrip.com/role/INDEBTEDNESSSummaryofDebtDetails_1" xlink:type="simple" xlink:href="bios-20210630.xsd#INDEBTEDNESSSummaryofDebtDetails_1"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/INDEBTEDNESSSummaryofDebtDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_93999c2c-7c79-46a0-a412-d0628e9d0f69" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_e9a7b352-16d9-4242-8f85-1e63053b3879" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_93999c2c-7c79-46a0-a412-d0628e9d0f69" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_e9a7b352-16d9-4242-8f85-1e63053b3879" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_7c2da685-10aa-4da4-96c7-52bd178a9d86" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_93999c2c-7c79-46a0-a412-d0628e9d0f69" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_7c2da685-10aa-4da4-96c7-52bd178a9d86" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_f928b03f-bc8b-4ff2-aea3-aff4b752ebee" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_93999c2c-7c79-46a0-a412-d0628e9d0f69" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_f928b03f-bc8b-4ff2-aea3-aff4b752ebee" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.bioscrip.com/role/INDEBTEDNESSLongTermDebtMaturitiesDetails" xlink:type="simple" xlink:href="bios-20210630.xsd#INDEBTEDNESSLongTermDebtMaturitiesDetails"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/INDEBTEDNESSLongTermDebtMaturitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_59d6d149-246a-42d7-9d1e-43f3f8783d67" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_b68a5d3b-0b4a-4128-9be0-928e236c0090" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_59d6d149-246a-42d7-9d1e-43f3f8783d67" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_b68a5d3b-0b4a-4128-9be0-928e236c0090" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_954e3329-8124-48c2-9314-687108b3bd69" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_59d6d149-246a-42d7-9d1e-43f3f8783d67" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_954e3329-8124-48c2-9314-687108b3bd69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_7b3c1316-3a1c-4290-8274-9acc349e1542" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_59d6d149-246a-42d7-9d1e-43f3f8783d67" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_7b3c1316-3a1c-4290-8274-9acc349e1542" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_c5ea159f-e283-4753-90da-0690cc59ce5a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_59d6d149-246a-42d7-9d1e-43f3f8783d67" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_c5ea159f-e283-4753-90da-0690cc59ce5a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_8503bd9d-b472-45c2-9860-1b61d5049246" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_59d6d149-246a-42d7-9d1e-43f3f8783d67" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_8503bd9d-b472-45c2-9860-1b61d5049246" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bios_LongTermDebtMaturityAfterYearFour_d81969f6-00ea-4d68-88db-966e8e05c021" xlink:href="bios-20210630.xsd#bios_LongTermDebtMaturityAfterYearFour"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_59d6d149-246a-42d7-9d1e-43f3f8783d67" xlink:to="loc_bios_LongTermDebtMaturityAfterYearFour_d81969f6-00ea-4d68-88db-966e8e05c021" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.bioscrip.com/role/DERIVATIVEINSTRUMENTSBalanceSheetLocationofDerivativesDetails" xlink:type="simple" xlink:href="bios-20210630.xsd#DERIVATIVEINSTRUMENTSBalanceSheetLocationofDerivativesDetails"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/DERIVATIVEINSTRUMENTSBalanceSheetLocationofDerivativesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_814b9514-5232-4fb7-8b18-b8abb982572f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityFairValueGrossLiabilityIncludingNotSubjectToMasterNettingArrangement_d4527f8b-14ce-4f3f-a268-1307664b8312" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLiabilityFairValueGrossLiabilityIncludingNotSubjectToMasterNettingArrangement"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeLiabilities_814b9514-5232-4fb7-8b18-b8abb982572f" xlink:to="loc_us-gaap_DerivativeLiabilityFairValueGrossLiabilityIncludingNotSubjectToMasterNettingArrangement_d4527f8b-14ce-4f3f-a268-1307664b8312" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.bioscrip.com/role/DERIVATIVEINSTRUMENTSPretaxGainLossonDerivativeInstrumentsDetails" xlink:type="simple" xlink:href="bios-20210630.xsd#DERIVATIVEINSTRUMENTSPretaxGainLossonDerivativeInstrumentsDetails"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/DERIVATIVEINSTRUMENTSPretaxGainLossonDerivativeInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeGainLossOnDerivativeNet_e4fc9a26-ed00-4214-b4fd-3bc6712b5133" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeGainLossOnDerivativeNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_7fccec70-a101-4e21-8946-5a3bc4c9494b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeGainLossOnDerivativeNet_e4fc9a26-ed00-4214-b4fd-3bc6712b5133" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_7fccec70-a101-4e21-8946-5a3bc4c9494b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_c96734e5-116f-48ec-aeef-0b25211f5638" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeGainLossOnDerivativeNet_e4fc9a26-ed00-4214-b4fd-3bc6712b5133" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_c96734e5-116f-48ec-aeef-0b25211f5638" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeReclassificationForDiscontinuanceBeforeTax_fd8e4d23-c094-4cc1-b176-1fbd62c6fdf4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeReclassificationForDiscontinuanceBeforeTax"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeGainLossOnDerivativeNet_e4fc9a26-ed00-4214-b4fd-3bc6712b5133" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeReclassificationForDiscontinuanceBeforeTax_fd8e4d23-c094-4cc1-b176-1fbd62c6fdf4" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
